On September 18, 2020, Grimm, Christopher; Lazzarotto, Mattia; Pompei, Simona; Schichler, Johanna; Richter, Nina; Farnberger, Judith E.; Fuchs, Michael; Kroutil, Wolfgang published an article.Safety of 1,2-Dimethoxybenzene The title of the article was Oxygen-free regioselective biocatalytic demethylation of methyl-ph ethers via methyltransfer employing veratrol-O-demethylase. And the article contained the following:
The cleavage of aryl Me ethers is a common reaction in chem. requiring rather harsh conditions; consequently, it is prone to undesired reactions and lacks regioselectivity. Nevertheless, O-demethylation of aryl Me ethers is a tool to valorize natural and pharmaceutical compounds by deprotecting reactive hydroxyl moieties. Various oxidative enzymes are known to catalyze this reaction at the expense of mol. oxygen, which may lead in the case of phenols/catechols to undesired side reactions (e.g., oxidation, polymerization). Here an oxygen-independent demethylation via Me transfer is presented employing a cobalamin-dependent veratrol-O-demethylase (vdmB). The biocatalytic demethylation transforms a variety of aryl Me ethers with two functional methoxy moieties either in 1,2-position or in 1,3-position. Biocatalytic reactions enabled, for instance, the regioselective monodemethylation of substituted 3,4-dimethoxy phenol as well as the monodemethylation of 1,3,5-trimethoxybenzene. The methyltransferase vdmB was also successfully applied for the regioselective demethylation of natural compounds such as papaverine and rac-yatein. The approach presented here represents an alternative to chem. and enzymic demethylation concepts and allows performing regioselective demethylation in the absence of oxygen under mild conditions, representing a valuable extension of the synthetic repertoire to modify pharmaceuticals and diversify natural products. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Safety of 1,2-Dimethoxybenzene
The Article related to biocatalytic demethylation methyl phenyl ether veratrol demethylase, Placeholder for records without volume info and other aspects.Safety of 1,2-Dimethoxybenzene
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem