Synthesis, DNA/RNA-interaction and biological activity of benzo[k,l]xanthene lignans was written by Tumir, Lidija-Marija;Zonjic, Iva;Zuna, Kristina;Brkanac, Sandra Radic;Jukic, Marijana;Hudjek, Ana;Durgo, Ksenija;Crnolatac, Ivo;Glavas-Obrovac, Ljubica;Cardullo, Nunzio;Pulvirenti, Luana;Muccilli, Vera;Tringali, Corrado;Stojkovic, Marijana Radic. And the article was included in Bioorganic Chemistry in 2020.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:
Interactions of two newly synthesized and six previously reported benzoxanthene lignans (BXLs), analogs of rare natural products, with DNA/RNA, G-quadruplex and HSA were evaluated by a set of spectrophotometric methods. Presence/absence of methoxy and hydroxy groups on the BX core and minor modifications at C-1/C-2 side pendants-presence/absence of Ph ring, methoxy and hydroxy groups on Ph ring-influenced the fluorescence changes and the binding strength to double-stranded (ds-) and G-quadruplex structures. In general, compounds without Ph ring showed stronger fluorescence changes upon binding than phenyl-substituted BXLs. On the other hand, BXLs with an unsubstituted Ph ring showed the best stabilization effects of G-quadruplex. CD spectroscopy results suggest mixed binding mode, groove binding and partial intercalation, to ds-DNA/RNA and end-stacking to top or bottom G-tetrads as the main binding modes of BXLs to those targets. All compounds exhibited micromolar binding affinities toward HSA and an increased protein thermal stability. Moderate to strong antiradical scavenging activity was observed for all BXLs with hydroxy groups at C-6, C-9 and C-10 positions of the BX core, except for derivative bearing methoxy groups at these positions. BXLs with unsubstituted or low-substituted Ph ring and one derivative without Ph ring showed strong growth inhibition of Gram-pos. Staphylococcus aureus. All compounds showed moderate to strong tumor cell growth-inhibitory activity and cytotoxicity. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol).
4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol
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Ether | (C2H5)2O – PubChem