Thiols Act as Methyl Traps in the Biocatalytic Demethylation of Guaiacol Derivatives was written by Pompei, Simona;Grimm, Christopher;Schiller, Christine;Schober, Lukas;Kroutil, Wolfgang. And the article was included in Angewandte Chemie, International Edition in 2021.Product Details of 2380-78-1 The following contents are mentioned in the article:
Demethylating Me Ph ethers is challenging, especially when the products are catechol derivatives prone to follow-up reactions. For biocatalytic demethylation, monooxygenases have previously been described requiring mol. oxygen which may cause oxidative side reactions. Here we show that such compounds can be demethylated anaerobically by using cobalamin-dependent methyltransferases exploiting thiols like Et 3-mercaptopropionate as a Me trap. Using just two equivalent of this reagent, a broad spectrum of substituted guaiacol derivatives were demethylated, with conversions mostly above 90%. This strategy was used to prepare the highly valuable antioxidant hydroxytyrosol on a one-gram scale in 97% isolated yield. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Product Details of 2380-78-1).
4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 2380-78-1
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem