Li, Aijun published the artcileImproved synthesis of nefazodone from phenol, Related Products of ethers-buliding-blocks, the main research area is nefazodone improved preparation; triazolone phenoxyethyl derivative nefazodone intermediate preparation.
A route for the synthesis of nefazodone (I) is reported. Nefazodone was obtained with an overall yield of 37.2% from phenol. The key steps involve the improved synthesis of 5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3(2H)-one (II), a key intermediate. The phenol was etherified with 1,2-dichloroethane (75%), followed by iodination-amination with NaI and CH3OH-NH3 (85.7%), acylation with Et chloroformate (95.7%) and cyclization with propionylhydrazine (83.6%).
Transactions of Tianjin University published new progress about nefazodone improved preparation; triazolone phenoxyethyl derivative nefazodone intermediate preparation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Related Products of ethers-buliding-blocks.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem