Ali, Shoukath M. published the artcileEndoxifen is a new potent inhibitor of PKC: A potential therapeutic agent for bipolar disorder, Recommanded Product: (2-Chloroethoxy)benzene, the main research area is endoxifen preparation PKC inhibitor bipolar disorder.
Protein kinase C (PKC) plays a major role in regulation of both pre and postsynaptic neurotransmission. Excessive activation of PKC results in symptoms related to bipolar disorder. Tamoxifen, a widely used breast cancer drug is known to inhibit PKC and demonstrate antimanic properties in human. We describe herein the synthesis of endoxifen, a tamoxifen active metabolite and compared its PKC inhibitory activity with that of tamoxifen. Endoxifen exhibited fourfold higher potency compared to tamoxifen.
Bioorganic & Medicinal Chemistry Letters published new progress about Antipsychotics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Recommanded Product: (2-Chloroethoxy)benzene.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem