Luong, Tuan Minh published the artcileTotal Asymmetric Synthesis and Stereochemical Confirmation of (+)- and (-)-Lyoniresinol and Its Deuterated Analogues, Quality Control of 134-96-3, the publication is Journal of Organic Chemistry (2022), 87(6), 4254-4262, database is CAplus and MEDLINE.
Lyoniresinol and its derivatives are lignans which have been isolated from a plethora of plant species. In addition to exhibiting a range of interesting biol. activities including anticancer, anti-inflammatory, antimicrobial, and others, these compounds have also been discovered in wines and spirits and shown to have gustatory effects in these alc. matrixes. (+)-Lyoniresinol 1 is reported to impart a strong bitter taste while its enantiomer (-)-lyoniresinol 2 is tasteless. The first total asym. synthesis of both natural enantiomers (+)-1 and (-)-2 and their deuterated analogs (D4)-(+)-3 and (D4)-(-)-4 has been achieved, confirming the structure and stereochem. of the natural products. The synthesized compounds can be utilized as internal standards in stable isotope dilution anal. for improving and optimizing the existing lyoniresinol quantitation methods in the future.
Journal of Organic Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Quality Control of 134-96-3.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem