Zhao, Lingyue published the artcileDesign, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors, Product Details of C8H11NO, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2022), 37(1), 462-471, database is CAplus and MEDLINE.
Kv1.5 potassium channel, encoded by KCNA5, is a promising target for the treatment of atrial fibrillation, one of the common arrhythmia. A new series of arylmethylpiperidines derivatives based on were synthesized and evaluated for their ability to inhibit Kv1.5 channel. Among them, compound showed good inhibitory activity (IC50 = 0.72 μM), preferable anti-arrhythmic effects and favored safety. These results indicate that can be a promising Kv1.5 inhibitor for further studies.
Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C4H5NS2, Product Details of C8H11NO.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem