Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists was written by Arienzo, Rosa;Clark, David E.;Cramp, Sue;Daly, Stephen;Dyke, Hazel J.;Lockey, Peter;Norman, Dennis;Roach, Alan G.;Stuttle, Keith;Tomlinson, Maxine;Wong, Melanie;Wren, Stephen P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Computed Properties of C9H10O4 This article mentions the following:
A new series of 2-aminoquinolines, e.g. I [R1R2N = N-methylpiperazino, morpholino, piperidino, etc.; R1 = Me2CH, cyclopentyl, R2 = H; R1 = Me, PhCH2, R2 = Me; R3 = Ph, 4-ClC6H4, 4-F3CC6H4, 2,4-Cl2C6H3, etc.] has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Computed Properties of C9H10O4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Computed Properties of C9H10O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem