Synthesis and antimicrobial evaluation of newly synthesized triazolothiadiazole analogs was written by Ramesh, D. K.;Krishna, B. Gopala;Mruthyunjaya, J. H.;Katagi, Manjunatha S.;Bolakatti, Girish. And the article was included in International Journal of Drug Design and Discovery in 2013.Formula: C9H10O4 This article mentions the following:
This study reports the successful synthesis of some new triazolothiadiazoles. The newly synthesized compounds were tested for antimicrobial activity against Staphylococcus aureus, Bacillus substilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger by measuring the zone of inhibition at concentration 125 μg/mL. Among the synthesized compounds I (R = 2-Cl; 4-Cl), II and III showed significant activity. In general compounds with Me and methoxy substituents exhibit lower growth inhibitory activity compared to chloro substituent and growth inhibition was found to be relevant to that of the standard drugs. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Formula: C9H10O4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Formula: C9H10O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem