Segizbayev, Medet et al. published their research in Dalton Transactions in 2020 | CAS: 63071-12-5

(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Transfer hydrogenation of aldehydes and ketones catalyzed using an aminophosphinite POCNH pincer complex of Ni(II) was written by Segizbayev, Medet;Oztopcu, Ozgur;Hayrapetyan, Davit;Shakhman, Dinmukhamed;Lyssenko, Konstantin A.;Khalimon, Andrey Y.. And the article was included in Dalton Transactions in 2020.Category: ethers-buliding-blocks This article mentions the following:

The aminophosphinite pincer complex (POCNH)NiBr was found to effectively catalyze the transfer hydrogenation of aldehydes RCHO (R = Ph, thiophen-2-yl, 3-methoxyphenyl, etc.) and ketones R1C(O)R2 (R1 = Et, Ph, 2-methoxypyridin-6-yl, etc.; R2 = Me, Ph, 2-phenylethyl, Et; R1R2 = -(CH2)5-) with 2-propanol and KOtBu as a base, presenting a rare example of bifunctional nickel transfer hydrogenation catalysts. The transfer hydrogenation of aldehydes and ketones was found to be selective, tolerating a wide range of other functional groups, including those prone to reduction such as esters, amides, alkenes, pyridines, and nitriles. The reactions were suggested to proceed via the metal-ligand cooperative mechanism with an intermediacy of an amido (POCN)NiII species. In the experiment, the researchers used many compounds, for example, (6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5Category: ethers-buliding-blocks).

(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem