Second generation 4-(4-methyl-1H-indol-5-ylamino)-2-phenylthieno[2,3-b]pyridine-5-carbonitrile PKCθ inhibitors was written by Wu, Biqi;Boschelli, Diane H.;Lee, Julie;Yang, Xiaoke;Chaudhary, Divya. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.SDS of cas: 480424-49-5 This article mentions the following:
Thieno[2,3-b]pyridine-5-carbonitrile 16 with a 4-methyl-5-indolylamine at C-4 and a 5-methoxy-2-(dimethylamino)-methylphenyl group at C-2 had an IC50 value of 16 nM for the inhibition of PKCθ. While moderate inhibition of PKCδ was also observed (IC50 = 130 nM), 16 had IC50 values of greater than 5 μM against Lyn and other members of the Src kinase family. In the experiment, the researchers used many compounds, for example, 3-Formyl-2-methoxyphenylboronic acid (cas: 480424-49-5SDS of cas: 480424-49-5).
3-Formyl-2-methoxyphenylboronic acid (cas: 480424-49-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.SDS of cas: 480424-49-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem