Zhong, Yan et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2016 | CAS: 1877-75-4

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid

Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents was written by Zhong, Yan;Xu, Yi;Zhang, Ai-Xia;Li, Xiao-Feng;Xu, Zhao-Ying;Li, Ping;Wu, Bin. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

A series of new aryloxyacetamide derivatives are designed and synthesized. Their protective activities against the glutamate-induced cell death were investigated in differentiated rat pheochromocytoma cells (PC12 cells). Most compounds exhibited neuroprotective effects, especially for I (R1 = 2-OMe, R2 = 4-F; R1 = 4-Br, R2 = 4-F) and II (R2 = 2-CO2Me, 2-OEt), which showed potential protection of PC12 cells at three doses (0.1, 1.0, 10 μM). MTT assay, Hoechst 33342/PI double staining, and high content screening (HCS) revealed that pretreatment of the cells with I (R1 = 2-OMe, R2 = 4-F; R1 = 4-Br, R2 = 4-F) and II (R2 = 2-CO2Me, 2-OEt) has significantly decreased the extent of cell apoptosis in a dose-dependent manner. The results of western blot anal. demonstrated these compounds suppressed apoptosis of glutamate-induced PC12 cells via caspase-3 pathway. These compounds can be lead compounds for further discovery of neuroprotective agents for treating cerebral ischemic stroke. Basic structure-activity relationships are also presented. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem