Synthetic sweetening agents-a survey of the materials available, including cyclamates was written by Bottle, R. T.. And the article was included in Manufacturing Chemist (1930-1963) in 1964.Safety of 3-Methyl-4-nitroanisole This article mentions the following:
Twenty-two substances with their resp. sweetness were listed as compared to sucrose. Especially strong were sweeteners such as stevioside, glycyrrhizin, and 3-(2-benzimidazolyl)propionic acid nicotinate. Saccharin and the cyclamates are the 2 most important synthetic sweeteners, since they are the only ones considered safe for use in foods. 30 references. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Safety of 3-Methyl-4-nitroanisole).
3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Safety of 3-Methyl-4-nitroanisole
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem