Identification and optimization of novel 1,3,4-oxadiazole EP1 receptor antagonists was written by Hall, Adrian;Brown, Susan H.;Chowdhury, Anita;Giblin, Gerard M. P.;Gibson, Mairi;Healy, Mark P.;Livermore, David G.;McArthur Wilson, Richard J.;Naylor, Alan;Rawlings, D. Anthony;Roman, Shilina;Ward, Emma;Willay, Caroline. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Formula: C9H10O4 This article mentions the following:
A novel series of oxadiazole EP1 receptor antagonists was identified by replacing the amide of a known glycine sulfonamide derivative with a 1,3,4-oxadiazole. Optimization of the substitution patterns on the three aromatic rings led to the identification of high affinity EP1 receptor antagonists. The derivative with highest affinity displayed a binding IC50 of 2.5 nM (pIC50 8.6). In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Formula: C9H10O4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Formula: C9H10O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem