New triazolothiadiazole and triazolothiadiazine derivatives as kinesin Eg5 and HIV inhibitors: Synthesis, QSAR and modeling studies was written by Khan, Imtiaz;Hameed, Shahid;Al-Masoudi, Najim A.;Abdul-Reda, Nabeel A.;Simpson, Jim. And the article was included in Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences in 2015.Name: 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:
A new series of fused 1,2,4-triazoles, namely [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles I (R1 = 2-F-4-Cl-C6H3, furan-3-yl, pyrrol-2-yl, etc.) and II (R2 = 2-OH, 2-CH3, 4-F, etc.) as well as [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines III (R3 = 4-H3COC6H4, 4-FC6H4, biphen-4-yl, naphthalen-1-yl, etc.) were synthesized by the condensation of 4-amino-5-(furan-2-yl)-4H-1,2,4-triazole-3-thiol with substituted aromatic acids R1CO2H, substituted phenoxyacetic acids R2OCH2CO2H, and phenacyl bromides R3C(:O)CH2Br, resp. The structures of the newly synthesized compounds were established using spectroscopic anal., while that of I (R1 = 4-FC6H4CH2) was confirmed independently by a single-crystal X-ray structure determination The compounds were evaluated for their antiviral activity against the replication of HIV-1 and HIV-2 in MT-4 cells using an MTT assay. In a docking study, II (R2 = 4-OH) interacted with several amino acids in the reverse transcriptase (RT) binding site of HIV-1. Some new analogs were selected for evaluation of their Eg5 inhibitory activity using an in vitro malachite green ATPase assay, the QSAR of these new analogs was studied as well. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Name: 2-(4-Methoxyphenoxy)acetic acid).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Name: 2-(4-Methoxyphenoxy)acetic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem