Solvent-free synthesis of 2-amino-5-aryloxymenthyl-1,3,4-thiadiazoles and their coumarin or benzofuran bis-heterocyclic derivatives was written by Li, Zheng;Yu, Jin-Lan;Yang, Jing-Ya;Zhu, Wei;Zhao, Yan-Long;Xing, Yu-Lin;Wang, Xi-Cun. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2006.Computed Properties of C9H10O4 This article mentions the following:
2-Amino-5-aryloxymethyl-1,3,4-thiadiazoles were synthesized rapidly by a microwave-accelerated solvent-free procedure in high yield via the condensation of thiosemicarbazide with aryloxyacetic acids using poly(ethyleneglycol)-supported dichlorophosphate as a dehydration reagent. The solvent-free N-acylation of 2-amino-5-aryloxymethyl-1,3,4-thiadiazoles with coumarin-3-carboxylic acid chloride or benzofuran-2-carboxylic acid chloride efficiently afforded corresponding bis-heterocyclic derivatives, 2-(coumarin-3-carboxamido)-5-aryloxymethyl-1,3,4-thiadiazoles, and 2-(benzofuran-2-carboxamido)-5-aryloxymethyl-1,3,4-thiadiazoles. The strategy has advantages of no organic solvent pollution, an elevated reaction rate, an improved yield, and a simple work-up procedure. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Computed Properties of C9H10O4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Computed Properties of C9H10O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem