Construction of substituted pyrazolo[4,3-c]quinolines via [5+1] cyclization of pyrazole-arylamines with alcohols/amines in one pot was written by Tang, Dong;Mu, Yangxiu;Iqbal, Zafar;He, Lili;Jiang, Rui;Hou, Jing;Yang, Zhixiang;Yang, Minghua. And the article was included in Journal of Heterocyclic Chemistry in 2022.Safety of (4-Methoxyphenyl)methanol This article mentions the following:
An efficient protocol had been developed for the synthesis of pyrazolo[4,3-c]quinoline derivatives I [R1 = Me, Ph, 3-pyridyl, etc.; R2 = Ph, 4-MeC6H4, 4-ClC6H4, 4-BrC6H4, 4-NCC6H4; R3 = Ph, 1-naphthyl, 2-thienyl, etc.], by reacting (1H-pyrazol-5-yl)anilines and readily available alcs./amines. A wide range of substrates with diverse functional groups were smoothly converted to the corresponding products in moderate to good yields, under optimal reaction conditions. Furthermore, the strategy also proceeded well with thiol and amino acid to access pyrazolo[4,3-c]quinoline derivatives In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Safety of (4-Methoxyphenyl)methanol).
(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Safety of (4-Methoxyphenyl)methanol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem