1-[(Ethoxyamino)methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins: a new class of antianaphylactic agents was written by TenBrink, Ruth E.;McCall, John M.;Johnson, Herbert G.. And the article was included in Journal of Medicinal Chemistry in 1980.Reference of 3929-47-3 This article mentions the following:
Benzoxepinylethanolamines I [RR1 = (CH2CH2)2NR2, R2 = 2-MeOC6H4, 2-pyridyl, 4-FC6H4, Me; R = H, R1 = CH2CH2OH] were prepared in 62-92% yields. Reduction of 3,4-(MeO)2C6H3CH2CH2CO2H followed by cyclocondensation with BrCH2CH(OEt)2 gave II (R3 = CH2Br, III). Treating III with HOCH2CH2OH in the presence of Et3N gave II (R3 = CH2OCH2CH2OH) which was esterified by 4-O2NC6H4SO2Cl and stirred with IV (R2 = 2-MeOC6H4) in the presence of Et3N at 25° for 24 h to give I [RR1= (CH2CH2)2NC6H4OMe-2]. Heating III with ClCH2CH2OH in the presence of BaCO3 at 90° for 46 h gave II (R3 = CH2OCH2CH2Cl) which was treated with IV (R2 = 2-pyridyl, 4-FC6H4, Me) or HOCH2CH2NH2 to give the corresponding I. The arylpiperazine compounds I [RR1 = (CH2CH2)2NR2, R2 = 2-MeOC6H4, 2-pyridyl 4-FC6H4] had good activity, i.e., 100%, 94% and 52% inhibition resp., in the rat passive cutaneous anaphylaxis test at 50 mg/kg, p.o. I [RR1 = (CH2CH2)2NMe, R1 = H, R1 = CH2CH2OH] were both inactive. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Reference of 3929-47-3).
3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Reference of 3929-47-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem