On July 31, 2013, Liu, Zong-ying; Wang, Yue-ming; Han, Yan-xing; Liu, Ling; Jin, Jie; Yi, Hong; Li, Zhuo-rong; Jiang, Jian-dong; Boykin, David W. published an article.Recommanded Product: 1-Fluoro-2-methoxybenzene The title of the article was Synthesis and antitumor activity of novel 3,4-diaryl squaric acid analogs. And the article contained the following:
A series of novel 3,4-diaryl squaric acid analogs 4a-r related to combretastatin A-4 (CA4) using squaric acid as the cis-restricted linker were prepared and studied for their anticancer activity against selected human cancer cell lines. New compounds 4g, 4k, 4m, 4n, 4p, 4q and 4r exhibit strong activities against human leukemia cells with IC50 values of ≤20 nM and compounds 4k, 4n, 4p, 4q and 4r showed potent activities against a panel of human tumor cell lines. Compounds 4n and 4p arrest tumor cell cycle in G2-M phase. Computational modeling anal. suggests that the binding mechanism of compound 4n to the colchicine binding site on the microtubules is similar to that of CA4. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 1-Fluoro-2-methoxybenzene
The Article related to antitumor diaryl squaric acid analog, 3,4-diaryl squaric acid analogs, anticancer, cytotoxic agents, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Recommanded Product: 1-Fluoro-2-methoxybenzene
Referemce:
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Ether | (C2H5)2O – PubChem