On March 31, 2021, Wu, Zhuo; Wei, Feng; Wan, Bin; Zhang, Yanghui published an article.Application In Synthesis of 2-Methoxynaphthalene The title of the article was Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source. And the article contained the following:
A Me group can have a profound impact on the pharmacol. properties of organic mols. Hence, developing methylation methods and methylating reagents is essential in medicinal chem. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using di-Me carbonate as a Me source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biol. and pharmacol. active compounds The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Application In Synthesis of 2-Methoxynaphthalene
The Article related to palladium catalyzed ipso meta dimethylation, dimethylation ortho substituted iodoarene, carbonhydrogen activation cascade reaction dimethyl carbonate methyl source, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: General and other aspects.Application In Synthesis of 2-Methoxynaphthalene
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