Li, Yi-Xian; Ren, Iwaki; Kato, Atsushi; Jia, Yue-Mei; Fleet, George W. J.; Zhao, Xuan; Xiao, Min; Yu, Chu-Yi published an article in 2016, the title of the article was Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition.Computed Properties of 321-28-8 And the article contains the following content:
Fluorinated derivatives of radicamine A and radicamine B, I (R1 = F, R2 = R3 = H, R4 = OH; R1 = R3 = H, R2 = F, R4 = OH; R1 = R2 = H, R3 = F, R4 = OH; R1 = R2 = R3 = H, R4 = F) and II (R1 = F, R2 = H; R1 = H, R2 = F), resp., have been synthesized from D-arabinose-derived cyclic nitrone III. Structure-activity relationship studies showed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom. C-7 or C-11 fluorination of the aromatic ring decreased α-glucosidase inhibition of the derivatives, whereas C-8 or C-10 fluorination preserved glycosidase inhibitory activities. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Computed Properties of 321-28-8
The Article related to radicamine a b fluorinated preparation glycosidase inhibitor structure activity, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Computed Properties of 321-28-8
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