Increased intestinal permeability in older subjects impacts the beneficial effects of dietary polyphenols by modulating their bioavailability was written by Hidalgo-Liberona, Nicole;Gonzalez-Dominguez, Raul;Vegas, Esteban;Riso, Patrizia;Del Bo, Cristian;Bernardi, Stefano;Peron, Gregorio;Guglielmetti, Simone;Gargari, Giorgio;Kroon, Paul Antony;Cherubini, Antonio;Andres-Lacueva, Cristina. And the article was included in Journal of Agricultural and Food Chemistry in 2020.Formula: C9H12O3 The following contents are mentioned in the article:
Polyphenols have great potential in regulating intestinal health and ameliorating pathol. conditions related to increased intestinal permeability (IP). However, the efficacy of dietary interventions with these phytochems. may significantly be influenced by interindividual variability factors affecting their bioavailability and consequent biol. activity. In the present study, urine samples collected from older subjects undergoing a crossover intervention trial with polyphenol-rich foods were subjected to metabolomics anal. for investigating the impact of increased IP on the bioavailability of polyphenols. Interestingly, urinary levels of phase II and microbiota-derived metabolites were significantly different between subjects with healthier intestinal barrier integrity and those with increased IP disruption. Our results support that this IP-dependent impaired bioavailability of polyphenols could be attributed to disturbances in the gut microbial metabolism and phase II methylation processes. Furthermore, we also observed that microbiota-derived metabolites could be largely responsible for the biol. activity elicited by dietary polyphenols against age-related disrupted IP. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Formula: C9H12O3).
4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Formula: C9H12O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem