Memantine nanoemulsion: a new approach to treat Alzheimer’s disease was written by Kaur, Atinderpal;Nigam, Kuldeep;Srivastava, Sukriti;Tyagi, Amit;Dang, Shweta. And the article was included in Journal of Microencapsulation in 2020.Formula: C10H22O3 The following contents are mentioned in the article:
A nanoemulsion loaded with memantine for intranasal delivery to bypass the blood-brain barrier for the treatment of Alzheimer disease. The nanoemulsion was prepared using homogenisation and ultrasonication methods. The developed nanoemulsion was characterised, in vitro release and antioxidant potential was analyzed. The in vivo studies were carried out by radiolabelling the memantine with technetium pertechnetate. The finalised NE showed particle-size of ~11 nm and percentage transmittance of ~99%. The in vitro release studies showed 80% drug release in simulated nasal fluid. The nanoemulsion showed 98% cell viability and antioxidative assays confirmed that the encapsulation of memantine in a nanoemulsion sustained its antioxidative potential. Gamma images and biodistribution results also confirmed higher uptake of formulation with %radioactivity of 3.6 ± 0.18%/g at 1.5 h in brains of rats administered intranasally. The developed nanoemulsion could be used as a potential carrier of memantine for a direct nose to brain delivery. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Formula: C10H22O3).
2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C10H22O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem