Oguchi, Minoru published the artcileMolecular Design, Synthesis, and Hypoglycemic Activity of a Series of Thiazolidine-2,4-diones, Safety of 6-Methoxy-N2-methylpyridine-2,3-diamine, the publication is Journal of Medicinal Chemistry (2000), 43(16), 3052-3066, database is CAplus and MEDLINE.
A series of imidazopyridine thiazolidine-2,4-diones were designed and synthesized from their corresponding pyridines. These compounds represent conformationally restricted analogs of the novel hypoglycemic compound rosiglitazone. The series was evaluated for its effect on insulin-induced 3T3-L1 adipocyte differentiation in vitro and its hypoglycemic activity in the genetically diabetic KK mouse in vivo. The structure-activity relationships are discussed. On the basis of the in vivo potency, 5-[4-(5-methoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]thiazolidine-2,4-dione was selected as the candidate for further studies in a clin. setting.
Journal of Medicinal Chemistry published new progress about 90817-34-8. 90817-34-8 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Ether, name is 6-Methoxy-N2-methylpyridine-2,3-diamine, and the molecular formula is C7H11N3O, Safety of 6-Methoxy-N2-methylpyridine-2,3-diamine.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem