In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 707-07-3, name is (Trimethoxymethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C10H14O3
At room temperature, 20g (74.9mmol) methyl 1-(chloroacetyl)-2-oxoindolin-6-ylcarboxylate was dissolved in 50 ml of acetic anhydride. The mixture is heated at 124 C. Add dropwise 27.28g (149.8mmol) trimethyl orthobenzoate. React for 6h in the open to distill off the volatile parts of the reaction mixture. After the reaction, cooling to room temperature, precipitated crystal. turns on lathe does solvent, using 500 ml DCM (dichloromethane) dissolving the residue, added to the 1.5L in petroleum ether, to separate out the solid, room temperature stirring 3h, ice-bath 1h, filtered to obtain yellow solid 27.4g, the target compound, the yield is 95%.
The synthetic route of 707-07-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Southeast University; Ji, Min; Chen, Hao; Cai, Jin; Liu, Haidong; Li, Rui; (13 pag.)(2016);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem