Thermo-Promoted Reactions of Anthranils with Carboxylic Acids, Amines, Phenols, and Malononitrile under Catalyst-Free Conditions was written by Jiang, Jing;Cai, Xin;Hu, Yanwei;Liu, Xuejun;Chen, Xiaodong;Wang, Shun-Yi;Zhang, Yinan;Zhang, Shilei. And the article was included in Journal of Organic Chemistry in 2019.Category: ethers-buliding-blocks This article mentions the following:
A convenient and atom-economical procedure for the thermo-promoted reactions of anthranil with different substrates was developed. The catalyst-free process affords various useful building blocks with good to moderate yields. This chem. enables several step- and cost-effective approaches for biol. interesting mols. and provides an efficient platform for the investigation of untapped reactions at high temperature In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Category: ethers-buliding-blocks).
2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Category: ethers-buliding-blocks
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem