Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure-activity relationship, activity profile, mode of action, and molecular docking was written by Yildirim, Hatice;Yildiz, Mahmut;Bayrak, Nilufer;Mataraci-Kara, Emel;Ozbek-Celik, Berna;Otsuka, Masami;Fujita, Mikako;Radwan, Mohamed O.;TuYuN, Amac Fatih. And the article was included in RSC Advances in 2022.HPLC of Formula: 605-94-7 This article mentions the following:
In an attempt to develop effective and potentially active antibacterial and/or antifungal agents, we designed, synthesized, and characterized thiolated CoQ analogs (CoQ1-8) with an extensive antimicrobial study. The antimicrobial profile of these analogs was determined using four Gram-neg. bacteria, three Gram-pos. bacteria, and three fungi. Because of the fact that the thiolated CoQ analogs were quite effective on all tested Gram-pos. bacterial strains, including Staphylococcus aureus (ATCC 29213) and Enterococcus faecalis (ATCC 29212), the first two thiolated CoQ analogs emerged as potentially the most desirable ones in this series. Importantly, after the evaluation of the antibacterial and antifungal activity, we presented an initial structure-activity relationship for these CoQ analogs. In addition, the most promising thiolated CoQ analogs (CoQ1 and CoQ2) having the lowest MIC values on all tested Gram-pos. bacterial strains, were further evaluated for their inhibition capacities of biofilm formation after evaluating their in vitro potential antimicrobial activity against each of 20 clin. obtained resistant strains of Gram-pos. bacteria. CoQ1 and CoQ2 exhibited potential mol. interactions with S. aureus DNA gyrase in addition to excellent pharmacokinetics and lead-likeness profiles. Our findings offer important implications for a potential antimicrobial drug candidate, in particular for the treatment of infections caused by clin. resistant MRSA isolates. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7HPLC of Formula: 605-94-7).
2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.HPLC of Formula: 605-94-7
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem