A new diversity oriented and metal-free approach to highly functionalized 3H-pyrimidin-4-ones was written by Riva, Renata;Banfi, Luca;Basso, Andrea;Zito, Paola. And the article was included in Organic & Biomolecular Chemistry in 2011.Recommanded Product: 1877-75-4 This article mentions the following:
A new synthesis of functionalized 3H-pyrimidin-4-ones is presented. The strategy is based on the synthetic elaboration of readily available α-substituted β-ketoesters that, upon transformation into the corresponding acyl enamines, have been cyclized to give 6H-1,3-oxazin-6-ones. These reactive intermediates have been in turn cleanly converted into highly functionalized pyrimidinones, by treatment with an appropriate primary amine. The whole sequence does not need the use of any metal mediator or catalyst. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Recommanded Product: 1877-75-4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Recommanded Product: 1877-75-4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem