Rhodium-catalyzed asymmetric synthesis of 1,1-disubstituted 1,3-dihydrobenzo[c]furans from prochiral triynes and internal alkynes was written by Ye, Fei;Haddad, Mansour;Ratovelomanana-Vidal, Virginie;Michelet, Veronique. And the article was included in Catalysis Communications in 2018.Recommanded Product: 16356-02-8 This article mentions the following:
The cationic rhodium/BINAP system was found to be an efficient catalytic system for the [2+2+2] cycloaddition of prochiral triynes with internal alkynes. The optimization of the catalytic system allowed the construction of 1,1-disubstituted 1,3-dihydrobenzo[c]furans I [R1 = Me, n-Pr, t-Bu, Ph; R2 = n-Bu, Ph; R3 = Me, SiMe3; R4 = CH2OMe, CH2OAc, CH2OC(O)t-Bu, CH2CO2Me, CH2OC(O)Ph] containing a quaternary carbon stereogenic centers in fair yields and moderate enantiomeric excesses. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Recommanded Product: 16356-02-8).
1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 16356-02-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem