A regioselective synthesis of 1-haloisoquinolines via ruthenium-catalyzed cyclization of O-methylbenzohydroximoyl halides with alkynes was written by Chinnagolla, Ravi Kiran;Pimparkar, Sandeep;Jeganmohan, Masilamani. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2013.HPLC of Formula: 16356-02-8 This article mentions the following:
A ruthenium-catalyzed highly regioselective cyclization of substituted N-methoxy benzimidoyl halides with alkynes in the presence of CsOAc (25 mol%) to give substituted 1-halo and 1-alkoxy substituted isoquinolines in good to excellent yields is described. E.g., in presence of [(RuCl2(p-cymene))2] and CsOAc, reaction of 4-MeC6H4CCl:NOMe and PhCCMe gave 77% isoquinoline derivative (I). In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8HPLC of Formula: 16356-02-8).
1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.HPLC of Formula: 16356-02-8
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem