Ru Doped Hydrotalcite Catalyzed Borrowing Hydrogen-Mediated N-Alkylation of Benzamides, Sulfonamides, and Dehydrogenative Synthesis of Quinazolinones was written by Sardar, Bitan;Jamatia, Ramen;Samanta, Arup;Srimani, Dipankar. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 105-13-5 This article mentions the following:
An efficient Ru doped hydrotalcite catalyzed N-alkylation of benzamides and sulfonamides with alcs. via borrowing hydrogen catalysis is illustrated. Various primary alcs., including benzyl, heteroaryl, and aliphatic alcs., were alkylated in good to excellent yields. To shed light on the mechanistic details, several control studies and deuterium labeling experiments were performed. Mechanistic studies underpin that the reaction is going via a borrowing hydrogen pathway rather than an SN1 type mechanism. The reaction can be easily scaled up without any detrimental effect on the yield. The catalyst is also capable of synthesizing quinazolinone directly from 2-aminobenzamide and alcs. Successful recyclability and high reactivity highlight the practical applicability of the catalyst. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5SDS of cas: 105-13-5).
(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.SDS of cas: 105-13-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem