syn-Diastereoselective glycolate aldol addition reactions of an N(3)-(p-methoxyphenoxy)acetyloxazolidine-2-thione was written by Haynes, Craig S.;Goodman, Cassie A.;Bruce, Juandah;Genin, Sarah C.;Austermuehle, Brad J.;Leong, Victor L.;Leise, Austin R.;Larson, Robert;Hamaker, Christopher G.;Hitchcock, Shawn R.. And the article was included in Tetrahedron: Asymmetry in 2017.Application of 1877-75-4 This article mentions the following:
An N3-(p-methoxyphenoxy)acetyloxazolidine-2-thione was synthesized and employed in glycolate asym. aldol addition reactions with aromatic and aliphatic aldehydes. It was determined that the titanium tetrachloride medicated aldol reaction afforded diastereoselectivities that ranged from 75:25 to 94:6 when the reaction was conducted at -78°. The absolute stereochem. of the aldol adducts was determined by 1H NMR spectroscopy and X-ray crystallog. The 1H NMR spectra of the aldol adducts contained a signal (the α-proton of the glycolate position of the aldol side chain) that was highly deshielded due to conformational restriction about the N(3)-(p-methoxyphenoxy)acetyl side chain and the oxazolidine-2-thione auxiliary. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application of 1877-75-4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application of 1877-75-4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem