Electrochemically Induced Spirolactonization of α-(Methoxyphenoxy)alkanoic Acids into Quinone Ketals was written by Deffieux, Denis;Fabre, Isabelle;Courseille, Christian;Quideau, Stephane. And the article was included in Journal of Organic Chemistry in 2002.Quality Control of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:
Anodic oxidations of two series of α-(2-methoxyphenoxy)- and α-(4-methoxyphenoxy)alkanoic acids were studied both at the anal. and preparative scales in order to delineate mechanistic aspects of electrochem. induced spirolactonization and to develop synthetically useful orthoquinone bis- and monoketals. Although α-monomethylated carboxylic acids and acetic acid derivatives do not undergo any spiroannulation, α-dimethylated carboxylic acids furnished spirolactones in high yields. A gem-di-Me effect is invoked to explain these differences in cyclization capacity. Electrooxidation conditions can be selected to furnish quinone spirolactone bis- or monoketals. Chemoselective monohydrolysis of bisketals can also be accomplished in a stepwise fashion to furnish the corresponding spirolactone monoketals, but the ortho compound unfortunately dimerized in situ via a Diels-Alder process. An ECEC pathway is proposed to rationalize the observed spirolactonizations on the basis of cyclic voltammetry analyses. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Quality Control of 2-(4-Methoxyphenoxy)acetic acid).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Quality Control of 2-(4-Methoxyphenoxy)acetic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem