Zhou, Yan et al. published their research in Molecules in 2021 | CAS: 57179-35-8

3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 57179-35-8

Design, synthesis, and evaluation of dihydropyranopyrazole derivatives as novel PDE2 inhibitors for the treatment of Alzheimer’s disease was written by Zhou, Yan;Li, Jinjian;Yuan, Han;Su, Rui;Huang, Yue;Huang, Yiyou;Li, Zhe;Wu, Yinuo;Luo, Haibin;Zhang, Chen;Huang, Ling. And the article was included in Molecules in 2021.Reference of 57179-35-8 This article mentions the following:

In this study, (R)-LZ77 was obtained as a hit compound with moderate PDE2 inhibitory activity (IC50 = 261.3 nM) using a high-throughput virtual screening method based on mol. dynamics. Then, 28 dihydropyranopyrazole derivatives I [R1 = H, CH3O, Cl; R2 = H, CH3, CH3O, etc.; R3 = H, CH3, C6H5; R4 = H, CH3O, Cl, etc; R5 = NH2, (CH3)2N; n = 1, 2, 3] and II [R6 = Cl, CF3; n = 0, 2, 3] were designed and synthesized as PDE2 inhibitors. Among them, compound (+)-I [R1 = H; R2 = CH3O; R3 = CH3; R4 = CF3; R5 = NH2; n = 1] was the most potent PDE2 inhibitor, with an IC50 value of 41.5 nM. The mol. docking of PDE2-(+)-I [R1 = H; R2 = CH3O; R3 = CH3; R4 = CF3; R5 = NH2; n = 1] revealed that the 4-(trifluoromethyl)benzyloxyl side chain of the compound enters the H-pocket and forms strong hydrophobic interactions with L770/L809/F862, which improves inhibitory activity. The above results may provide insight for further structural optimization of highly potent PDE2 inhibitors and may lay the foundation for their use in the treatment of AD. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8Reference of 57179-35-8).

3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 57179-35-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem