Biosynthesis of 4-acetylantroquinonol B in Antrodia cinnamomea via a pathway related to coenzyme Q synthesis was written by Yang, Shang-Han;Lin, Yu-Wei;Chiang, Been-Huang. And the article was included in Biochemical Engineering Journal in 2017.Formula: C9H10O4 This article mentions the following:
The biosynthesis pathway for production of 4-acetylantroquinonol B (4-AAQB) by Antrodia cinnamomea was investigated by adding various precursors to the culture medium. Adding 4-hydroxybenzoic acid (4-HBA) significantly increased the production of 4-AAQB. Since 4-HBA is an intermediate of the shikimate pathway and 4-AAQB and coenzyme Q (CoQ) are similar in structure, we suspected that the pathway for producing 4-AAQB was closely related to the biosynthesis of CoQ. Since the isoprenoid chain of CoQ is synthesized via the mevalonate pathway, we added oleic acid to the culture medium and confirmed that the addition significantly increased the production of 4-AAQB. Furthermore, adding coenzyme Q0 into the fermentation broth was found to be the most effective way to increase the production of 4-AAQB. We suspect that coenzyme Q0 forms CoQ, after which CoQ is converted to 4-AAQB via unknown steps. The increase in 4-AAQB production due to the addition of CoQ10 further demonstrated that the biosynthesis pathway of 4-AAQB from A. cinnamomea is closely related to CoQ. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Formula: C9H10O4).
2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Formula: C9H10O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem