Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate was written by Mo, Wenyan;Shi, Yanxia;He, Junbo;Li, Baoju;Peng, Hao;He, Hongwu. And the article was included in Journal of Heterocyclic Chemistry in 2016.Related Products of 1877-75-4 This article mentions the following:
A series of novel Et 4-(methyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates I [R1 = 4-CH3, 4-OCH3, 4-Cl, etc.] and Et 4-(trifluoromethyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates II [R1 = H, 4-CH3, 4-OCH3, 4-Cl] were synthesized, and their structures were confirmed by IR, 1H-NMR, MS spectra and elemental anal. The results of preliminary bioassays show that some of the title compounds exhibited moderate to good herbicidal activities. Compared with the fluorine free compounds I [R1 = 4-F, 2,4-Cl2, 2-Cl,4-F], the compounds bearing fluorine II [R1 = 4-F, 2,4-Cl2, 2-Cl,4-F] showed higher herbicidal activities with 70-100% inhibition against Capsella bursa-pastoris, Amaranthus restroflexus, and Eclipta prostrata at the dosage of 150 g/ha, which indicated that the trifluoromethyl on the thiazole ring was beneficial for the herbicidal activity. Furthermore, compounds II were tested for fungicidal activity against Pseudoperonospora cubensis at 500 娓璯/mL. Compounds II [R1 = H, 4-F] showed the best fungicidal activity with more than 80% inhibition. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Related Products of 1877-75-4).
2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 1877-75-4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem