Ju, Zhiran et al. published their research in Bioorganic Chemistry in 2020 | CAS: 111-77-3

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C5H12O3

Anti-inflammatory effects of an optimized PPAR-绾?agonist via NF-榄廈 pathway inhibition was written by Ju, Zhiran;Su, Mingzhi;Hong, Jongki;Kim, Eun La;Jung, Jee H.. And the article was included in Bioorganic Chemistry in 2020.Formula: C5H12O3 This article mentions the following:

In our previous study, a PPAR-绾?agonist (+)-(R,E)-6a1 was elaborated as an anti-inflammatory lead. However, in silico anal. showed that (+)-(R,E)-6a1 lacks key hydrogen bonding with Tyr473 of PPAR-绾?LBD (ligand binding domain). To facilitate addnl. hydrogen bonding with Tyr473, a more polar head group was introduced to the structure of (+)-(R,E)-6a1, and we also attempted to synthesize enzymically stable derivatives Of the synthetic derivatives, compound (+)-(R,E)-5f showed highest PPAR-绾?transcriptional activity and reasonable metabolic stability. Compound (+)-(R,E)-5f suppressed the expression of pro-inflammatory mediators such as inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin 6 (IL-6), and tumor necrosis factor-浼?(TNF-浼?. Reduction of nitric oxide (NO), and ROS was also observed Compound (+)-(R,E)-5f was found to suppress the NF-榄廈 pathway by inhibiting phosphorylation of IKK (I榄廈 kinase), and this may lead to subsequent inhibition of I榄廈浼?(inhibitor of NF-榄廈浼? phosphorylation and inhibition of NF-榄廈 activation. These results indicate that (+)-(R,E)-5f exerts anti-inflammatory activity via NF-榄廈 pathway inhibition, and may serve as a potential anti-inflammatory lead. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Formula: C5H12O3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C5H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem