A Unifying Synthesis Approach to the C18-, C19-, and C20-Diterpenoid Alkaloids was written by Kou, Kevin G. M.;Kulyk, Svitlana;Marth, Christopher J.;Lee, Jack C.;Doering, Nicolle A.;Li, Beryl X.;Gallego, Gary M.;Lebold, Terry P.;Sarpong, Richmond. And the article was included in Journal of the American Chemical Society in 2017.Synthetic Route of C6H10O2 This article mentions the following:
The secondary metabolites that comprise the diterpenoid alkaloids are categorized into C18-, C19-, and C20-families depending on the number of contiguous carbon atoms that constitute their central framework. Herein, we detail our efforts to prepare these mols. by chem. synthesis, including a photochem. approach, and ultimately a bioinspired strategy that has resulted in the development of a unifying synthesis of one C18 (weisaconitine D), one C19 (liljestrandinine), and three C20 (cochlearenine, paniculamine, and N-ethyl-1浼?hydroxy-17-veratroyldictyzine) natural products from a common intermediate. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Synthetic Route of C6H10O2).
1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Synthetic Route of C6H10O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem