321-28-8, Adding some certain compound to certain chemical reactions, such as: 321-28-8, name is 1-Fluoro-2-methoxybenzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 321-28-8.
Step 1: Preparation of 3′-fluoro-4′-methoxy-acetophenone. acetyl chloride (51.0 g, 0.65 mol) was added dropwise to a stirred solution of aluminum chloride (80.0 g, 0.6 mol) and chloroform (750 ML), maintaining the temperature between 5-10 C. The mixture was stirred for 10 minutes at 5 C. before the dropwise addition of 2-fluoroanisole (62.6 g, 0.5 mol).. The mixture was stirred at 0-10 C. for 1 hour and poured into ice (1 L).. The resultant layers were separated and the aqueous layer was extracted with dichloromethane (2*250 ML).. The combined organic layers were washed with water (2*150 ML), dried over anhydrous MgSO4, filtered and concentrated in vacuo to a volume of 300 ML. Hexanes were added and a white solid formed which was isolated by filtration and air dried.. This material was recrystallized from a mixture of dichloromethane and hexanes to afford (77.2 g, 92%) of material suitable for use in the next step: mp 92-94 C.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 321-28-8.
Reference:
Patent; G. D. Searle & Co.; US6342510; (2002); B1;,
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