Synthetic Route of 150-78-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 150-78-7 as follows.
General procedure: To a mixture of DITB (2, 517.7 mg, 1.10 mmol), oxone (681.0 mg, 1.11 mmol) in acetonitrile (4.5 mL) and HFIP (1.5 mL) was added 2-methoxynaphthalene (6c, 476.5 mg, 3.01 mmol), and the mixture was stirred for 24 h at 50 C. The reaction mixture was then diluted with ether and quenched with aqueous NaHCO3, and extracted with ether (15 mL x 3). The combined organic layers were washed with water (15 mL x 1), dried over Na2SO4, filtrated, and concentrated in vacuo. The residue was purified by silica gel column chromatography (eluent: hexane / chloroform = 5 / 1) to afford 1-bromo-2-methoxynaphthalene (7c, 578.5 mg, 81%) [S8].
According to the analysis of related databases, 150-78-7, the application of this compound in the production field has become more and more popular.