Application of 102-52-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 102-52-3 as follows.
Preparation of 5-(3-methoxy-4-(1H-pyrazol-1-yl)phenyl)oxazole (IIe) To a suspension of intermediate IId (1.834 g, 8.94 mmol) in EtOH (30 ml) were added malonaldehyde bis(dimethyl acetal) (1.63 ml, 9.84 mmol) and conc.HCl (1 ml). The reaction mixture was stirred at 70 C. for 2 hours. The cooled mixture was evaporated to dryness, diluted saturated solution of NaHCO3 and extracted with EtOAc twice. The combined organics were washed with water, with saturated solution of NaCl, dried over MgSO4, filtered and evaporated. The final product was purified by silica gel chromatography using 0 to 30% EtOAc/cyclohexane as eluent to give intermediate IIe (1.380 g, 64%). 1H NMR (500 MHz, CDCl3) delta 8.12 (d, J=2.1 Hz, 1H), 7.94 (s, 1H), 7.85 (d, J=8.3 Hz, 1H), 7.72 (d, J=1.4 Hz, 1H), 7.40 (s, 1H), 7.36 (dd, J=8.3, 1.8 Hz, 1H), 7.32 (d, J=1.7 Hz, 1H), 6.46-6.43 (m, 1H), 3.97 (s, 3H).
According to the analysis of related databases, 102-52-3, the application of this compound in the production field has become more and more popular.