Adding a certain compound to certain chemical reactions, such as: 2688-84-8, name is 2-Phenoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2688-84-8, Formula: C12H11NO
Exemplary Compound B-16 was synthesized from the intermediate 3. The intermediate 3 (332 mg, 0.5 mmol), 2-phenoxyaniline (55 6 mg, 3 mmol), and ethanol (10 ml) were charged in a reaction container, and then stirred under heating and refluxing for 8 hours. After the completion of a reaction, the ethanol was vacuum-removed, and then ethyl acetate was added to deposit a precipitate. Filtering was performed, the obtained crystal was dissolved in water, an aqueous solution in which potassium hexafluorophosphate (1 g) was dissolved was added dropwise, the resultant substance was stirred at room temperature for 3 hours, and then the deposited crystal was filtered. The obtained crystal was recrystallized with isopropyl alcohol to give 323 mg (Yield: 81%) of Exemplary Compound B-16. The structure of Exemplary Compound B-16 was confirmed by NMR measurement. 1H NMR (CD3CN, 500 MHz) sigma (ppm): 9.13 (d, 2H), 9.01 (s, 1H), 8.97 (d, 1H), 8.25 (d, 2H), 8.09 (d, 1H), 7.78-7.64 (m, 4H), 7.45 (m, 6H), 7.28 (m, 2H), 7.14 (m, 6H), 3.93 (s, 3H), 3.92 (s, 3H), 2.50 (s, 3H)
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Reference:
Patent; CANON KABUSHIKI KAISHA; Igawa, Satoshi; Yamamoto, Jun; Yamada, Kenji; Tamura, Tetsuya; (31 pag.)US2017/329195; (2017); A1;,
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