Recently I am researching about POLYCHLORINATED-BIPHENYLS; ORGANOCHLORINE PESTICIDES; SERUM CONCENTRATIONS; ENVIRONMENTAL CHEMICALS; DISRUPTING CHEMICALS; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; EARLY-PREGNANCY; ADIPOSE-TISSUE; EXPOSURE, Saw an article supported by the National Institutes of Health’s Intramural Research Program at the Eunice Kennedy Shriver National Institute of Child Health and Human Development [HHSN275200800013C, HHSN275200800002I, HHSN27500006, HHSN275200800003IC, HHSN275200800014C, HHSN275200800012C, HHSN275200800028C, HHSN275201000009C, HHSN27500008]; EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [ZIAHD008967] Funding Source: NIH RePORTER. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Rahman, ML; Zhang, CL; Smarr, MM; Lee, S; Honda, M; Kannan, K; Tekola-Ayele, F; Louis, GMB. The CAS is 101-84-8. Through research, I have a further understanding and discovery of Diphenyl oxide. COA of Formula: C12H10O
Background: Persistent organic pollutants (POPs) are linked with insulin resistance and type-2 diabetes (T2D) in the general population. However, their associations with gestational diabetes (GDM) are inconsistent. Objective: We prospectively evaluated the associations of POPs measured in early pregnancy with GDM risk. We also assessed whether pre-pregnancy BMI (ppBMI) and family history of T2D modify this risk. Methods: In NICHD Fetal Growth Study, Singletons, we measured plasma concentration of 76 POPs, including 11 organochlorine pesticides (OCPs), 9 polybrominated diphenylethers (PBDEs), 44 polychlorinated biphenyls (PCBs), and 11 per-and polyfluoroalkyl substances (PFAS) among 2334 healthy non-obese women at 8-13 weeks of gestation. GDM was diagnosed by Carpenter and Coustan criteria. We constructed chemical networks using a weighted-correlation algorithm and examined the associations of individual chemical and chemical networks with GDM using multivariate Poisson regression with robust variance. Results: Higher concentrations of PCBs with six or more chlorine atoms were associated with increased risk of GDM in the overall cohort (risk ratios [RRs] range: 1.08-1.13 per 1-standard deviation [SD] increment) and among women with a family history of T2D (RRs range: 1.08-1.48 per 1-SD increment) or normal ppBMI (RRs range: 1.08-1.22 per 1-SD increment). Similar associations were observed for the chemical network comprised of PCBs with >= 6 chlorine atoms and the summary measure of total PCBs and non-dioxin like PCBs (138, 153, 170, 180). Furthermore, four PFAS congeners-perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluoroheptanoic acid (PFHpA), and perfluorododecanoic acid (PFDoDA)-showed significant positive associations with GDM among women with a family history of T2D (RRs range: 1.22-3.18 per 1-SD increment), whereas BDE47 and BDE153 showed significant positive associations among women without a family history of T2D. Conclusions: Environmentally relevant levels of heavily chlorinated PCBs and some PFAS and PBDEs were positively associated with GDM with suggestive effect modifications by family history of T2D and body adiposity status.
About Diphenyl oxide, If you have any questions, you can contact Rahman, ML; Zhang, CL; Smarr, MM; Lee, S; Honda, M; Kannan, K; Tekola-Ayele, F; Louis, GMB or concate me.. COA of Formula: C12H10O
Reference:
Ether – Wikipedia,
,Ether | (C2H5)2O – PubChem