Kim, Byung Hyun; Lee, Jong Gil; Kim, Woon Ki; Kim, Young Gyu published the artcile< Regioselective Synthesis of 2,6-Dimethyltetralin: Key Precursor to 2,6-Dimethylnaphthalene>, Quality Control of 52244-70-9, the main research area is tetralin dimethyl regioselective preparation; naphthalene dimethyl regioselective preparation; tetrahydronaphthalene regioselective preparation; alc arylbutyl preparation intramol Friedel Crafts alkylation.
A novel regioselective synthesis for 2,6-dimethyltetralin (2,6-DMT), a key precursor to 2,6-dimethylnaphthalene (2,6-DMN), is described. The synthesis comprises the following three steps; the Heck reaction between com. available 4-bromotoluene and 3-methyl-3-buten-1-ol, the catalytic reduction of the coupling products, and the acid-catalyzed cyclization of the alc. intermediate. The process has an advantage over the established processes in that 2,6-DMT is obtained as the only isomer, and the isomerization and/or the complicated separation and purification steps are not required to produce pure 2,6-DMT. 2,6-DMN could be also obtained as a major product depending on the cyclization conditions.
Organic Process Research & Development published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem