Nahan, Keaton; Sussman, Eric M.; Oktem, Berk; Schultheis, Lester; Wickramasekara, Samanthi published the artcile< Screening for extractables in additive-manufactured acrylonitrile butadiene styrene orthopedic cast>, Related Products of 18312-57-7, the main research area is acrylonitrile butadiene styrene orthopedic cast extractable safety; 3D printing; Acrylonitrile butadiene styrene (ABS); Additive manufacturing; Chemical characterization; Extractables; Medical devices.
The use of additive-manufactured components in medical applications, specifically medical devices (e.g., orthopedic casts), has increased in recent years. Such devices may be fabricated at the point of care using consumer-grade additive manufacturing Limited studies have been conducted to evaluate the extractable substances of these devices. Chem. characterization followed by toxicol. risk assessment is one means of evaluating safety of devices. This study was designed to determine the extractables profile of additive-manufactured materials according to filament grade and post-processing method. Feedstocks for additive manufacturing were tested as filament and manufactured casts, while the cast from consumer-grade filament (CGF) was post-processed. Samples were extracted using three solvents of varying polarities. Extracts were analyzed by gas chromatog./mass spectrometry (GC/MS) and liquid chromatog./mass spectrometry (LC/MS) techniques. In GC/MS anal., isopropanol extracts generated fewer compound identifications for USP Class VI filament (USPF)-based casts (3) compared with the resp. filament (17) while hexane generated the most compound identifications for the finished cast manufactured from CGF. CGF was found to have the highest number of nonvolatile extractables for isopropanol (15) and hexane (34) by pos. ion LC/MS. Addnl., CGF produced more non-polar extractables in hexane than the USPF. A known polymer byproduct and potential genotoxicant, styrene acrylonitrile (SAN) trimer, was one of the compounds identified in both GC/MS and LC/MS at quantities ranging from 19 to 270μg g-1. Overall these results suggested that the extractables profile was affected by the filament material, printing procedure, and post-processing method.
Talanta published new progress about Additive manufacturing. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Related Products of 18312-57-7.
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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem