The author of 《Improved Synthetic Process of Dimethyl 4-Oxo-4H-pyran-3,5-dicarboxylate》 were Hu, Xinquan; Ding, An; Sun, Nan; Hu, Baoxiang; Shen, Zhenlu; Jin, Liqun. And the article was published in Organic Process Research & Development in 2019. Product Details of 4637-24-5 The author mentioned the following in the article:
A reported two-step procedure for preparing di-Me 4-oxo-4H-pyran-3,5-dicarboxylate was extensively optimized. It was found that the reactions can be carried out in toluene as a single solvent and the product was directly obtained by a simple filtration. More importantly, considering potential solvent recovering and recycling, the effluent of the process can be remarkably reduced. This new process facilitated the potential scale-up with com. significance. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Product Details of 4637-24-5)
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Product Details of 4637-24-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem