36805-97-7, These common heterocyclic compound, 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Chloro-6-methoxymethyl-isonicotinic acid (3.48 g, 15.5 mmol, 1 eq) is dissolved in toluene (60 ml), and the solution is heated to 800C. N,N-dimethylformamide-di-tert-butylacetal (7.53 ml, 31 mmol, 2 eq) is added in portions over 8 h. The reaction mixture is then diluted with TBME and washed with aq NaHCO3. The organic layer is dried over sodium sulfate, filtered and concentrated to give the product.MS (ES+): 258 = [M+H]+. .HPLC (Nucleosil C18HD, 4×70 mm, 3 mum, 5-100% MeCN (6 min), 100% MeCN (1.5 min)) retention time: 6.24 min.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 36805-97-7.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/77004; (2007); A1;,
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