A common heterocyclic compound, 321-28-8, name is 1-Fluoro-2-methoxybenzene, molecular formula is C7H7FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 321-28-8.
The mixture of 2-chloro-5-nitrobenzoyl chloride (4.0 g, 18.18 mmol), 2-fluoroanisole (5.0 mL) and AlCl3 (3.63 g, 27.27 mmol) was stirred at room temperature for 24 h. The reaction mixture was poured into 10% HCl aqueous solution cooled in ice bath, which was extracted with EtOAc (100 mL ¡Á 3). The combined organic layer was washed with brine (100 mL ¡Á 1) and dried over anhydrous Na2SO4. The crude product was provided after evaporation and recrystalized with EtOAc to give compound 2b as white solid (5.40 g, 96%); mp 113-115 C; 1H NMR (DMSO-d6) delta (ppm): 8.41 (dd, J1 = 8.7 Hz, J2 = 2.4 Hz, 1H, ArH), 8.35 (d, J = 2.4 Hz, 1H, ArH), 7.88 (d, J = 8.7 Hz, 1H, ArH), 7.60-7.67 (m, 2H, ArH), 7.28 (t, J = 8.4 Hz, 1H, ArH), 4.01 (s, 3H, OCH3); HRMS (ESI): m/z, Calcd for C14H10ClFNO4 [M+H+]: 310.0277, Found 310.0297.
The synthetic route of 1-Fluoro-2-methoxybenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Chang; Jin, Jing; Chen, Liang; Zhou, Jie; Chen, Xiaoguang; Fu, Decai; Song, Hongrui; Xu, Bailing; Bioorganic and Medicinal Chemistry; vol. 20; 9; (2012); p. 2992 – 2999;,
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