In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2752-17-2, name is 2,2′-Oxydiethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 2752-17-2
General procedure: The parent compound 9 (0.36g, 1mmol) was dissolved in CH2Cl2 (6mL), then oxalyl chloride (4mmol) was added dropwise. The mixture was stirred for 4h at the room temperature. The solvent and excess oxalyl chloride was evaporated to obtain the crude farnesylthiosalicyl chloride. Then to a mixture of different diamines (1.5mmol) and TEA (0.45mmol) in 10mL CH2Cl2 was added dropwise the CH2Cl2 solution (5mL) of farnesylthiosalicyl chloride (1.12g, 0.3mmol) at 0C over 1h. After stirring for another 0.5h the reaction was quenched by adding 20mL water. The mixture was extracted with CH2Cl2 (20mL¡Á3) and the organic layer was combined, washed with brine, dried with anhydrous Na2SO4 and concentrated in vacuo. The crude product was separated by silica gel chromatography (petroleum ether/ethyl acetate=1:1 v/v; then CH2Cl2-MeOH=4:1 as the eluent) to afford compound 10a-g and 11a-g as yellowish oil.
The synthetic route of 2752-17-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ling, Yong; Wang, Zhiqiang; Zhu, Hongyan; Wang, Xuemin; Zhang, Wei; Wang, Xinyang; Chen, Li; Huang, Zhangjian; Zhang, Yihua; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 374 – 380;,
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