Adding a certain compound to certain chemical reactions, such as: 321-28-8, name is 1-Fluoro-2-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 321-28-8, 321-28-8
General procedure: To a 5 mL screw-capped vial equipped with a 15¡Á10 mm spinvane triangular-shaped Teflon stirbar, simple arene 1(0.5 mmol), saccharin (1.0 mmol), Selectfluor (1.0 mmol), K2CO3 (1.0 mmol) and CuCl (0.1 mmol) were added in nitromethane (3.0 mL). The mixture was sealed with aTeflon-lined cap and stirred at 90 C for 6.0 h (monitoredby TLC), extracted with dichloromethane (5¡Á3 mL), and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure, and the residue was purified by flash silica gel column chromatography to give aromatic amine 2. The characterizations of aromatic amines 2 and 4 were listed in the Supporting Information online.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Fluoro-2-methoxybenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Sun, Kai; Li, Yan; Zhang, Qian; Science China Chemistry; vol. 58; 8; (2015); p. 1354 – 1358;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem